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Methylene Blue Drops

USP Purity Methylene Blue 1% Drops, Enhanced with Nano Gold, Vitamin C & Fulvic Acid Trace Minerals

Era Organics Activated Methylene Blue is the only 1% methylene blue formula of its kind. Made at a leading American lab to be ultra-pure, 99.99% pharmaceutical-grade, and independently tested for purity and heavy metals.

What makes ours different

  • 99.99% PureUSP-purity methylene blue at 99.99% purity. Its certificate of analysis is on this page.
  • USP Purity · Pharmaceutical GradeHeld to the United States Pharmacopeia purity standard, not technical or lab grade.
  • Third-party testedThird-party tested for purity and for heavy metals (arsenic, cadmium, lead, mercury). Reports below.
  • Glass dropper bottleCobalt blue glass bottle with a glass dropper, so you can measure by the drop.
  • Made in USAMade in the USA by a family-owned company.
  • GMP-certified facilityMade in a GMP-certified facility.
  • Alcohol-freeNo alcohol in the formula.
  • Formaldehyde-freeNo formaldehyde in the formula.
Size

How would you like it?

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Guaranteed safe & secure checkout

The Empty Bottle Promise

Try it for 60 days. If you don't love it, we'll refund you, even if the bottle is empty.

Our Methylene Blue 1% Drops are made around purity and transparency. We start with USP grade methylene blue from a leading lab supplier, add vitamin C, colloidal gold (nano gold) and fulvic minerals, and stabilize it in organic vegetable glycerin. Made in the USA in a GMP-certified facility.

  • USP grade methylene blue, third-party tested for purity
  • Tested for heavy metals (arsenic, cadmium, lead, mercury) by a third-party lab
  • Cobalt blue glass bottle with a glass dropper
  • Alcohol-free and formaldehyde-free
  • Family owned, made in the USA, with our Empty Bottle Promise

Important: This product is sold for research and development purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

How is this different from cheaper or aquarium methylene blue?

Aquarium products are made for fish tanks, and many lab products don't state a grade or publish test results. Ours starts with USP-purity methylene blue, is third-party tested for purity and heavy metals with the reports on this page, and is made in the USA in a GMP-certified facility, alcohol-free and formaldehyde-free.

How do I know it's pure?

Read the reports. The methylene blue comes with a certificate of analysis, and the drops are third-party tested for arsenic, cadmium, lead and mercury. Both reports for the current batch are in the Lab results section.

Will it stain, and what does it taste like?

Yes, it's a strong blue dye. It can stain skin, fabric, counters and plastic, and tint your tongue for a while. Mix it into water in a glass, wipe drips right away, and rinse with water. On its own it tastes bitter; mixed into water or juice, the taste is much milder.

How long does it last, and how do I store it?

Keep the cap on tight and store the bottle in a cool, dark place away from sunlight. Use it by the date printed on the bottle.

Shipping information

We keep shipping simple and affordable for all U.S. orders:

  • Free DHL Ground Shipping on orders over $40
  • DHL Ground (4-8 business days) - $5.95 Flat Rate (under $40)
  • USPS Ground Advantage (2-5 business days)
  • FedEx 2 Day (2 business days)

Orders are fulfilled within 24-48 hours, Monday-Friday. Shipping time starts from shipping confirmation.

  • 99.99% Pure
    USP purity · pharmaceutical grade
  • Third-party tested
    for purity and heavy metals
  • Made in USA
    in a GMP-certified facility
  • Family owned since 2015
    made in the USA
Customer reviews

What customers say

  • Nick★★★★★
    ✓ Verified purchase
    “Love the quality compared to others I’ve tried. Cleaner taste and feeling the difference after just a week.”
  • Beau★★★★★
    ✓ Verified purchase
    “Wow what a difference this has been. After just a week I have more mental clarity. Love the purity of the methylene blue and the extra ingredients they’ve added. What a game changer.”
  • A Tired Mom★★★★★
    ✓ Verified purchase
    “I can really tell the difference with my mental clarity and focus while using it. I feel extra fancy with the nano gold in it lol”
  • Anonymous★★★★★
    ✓ Verified purchase
    “…all day energy and serious mental clarity. It’s like I took the Limitless pill from the movie. My focus is improved and don’t get as mentally overwhelmed as I used to. Era never cuts corners and it really shows with the results.”
  • Michael★★★★★
    “Ive tried other brands of methylene blue which were pretty good, but to be honest, after trying this one this brand is much better! The focus and drive is instantly there minus the overcaffeinated jitter feeling.”
  • denvee★★★★★
    “…Where this one stands out is the packaging and overall quality feel. The bottles are thick and well made, and the labels look clean and professional. It gives me more confidence in what I’m using, rather than wondering about the quality…”
Know what you're buying

Not all methylene blue is the same

Most methylene blue sold online is technical or lab grade, made for dyes and stains, with no purity standard. Ours is USP purity · pharmaceutical grade at 99.99% purity, third-party tested for purity and heavy metals.

USP Purity · Pharmaceutical Grade (Era Organics)Technical / Lab Grade (Most Brands)
Purity standard99.99%Unspecified
Pharmaceutical-grade purity verifiedYesNo
3rd party testedYesRarely
Heavy metal screeningYesNot required
Lab reports you can readOn this pageRarely published
Hidden impuritiesNonePossible
Alcohol-freeYesNo
Formaldehyde-freeYesNo
GMP certified facilityYesNo
Concentration1% (about 0.5 mg per drop)Varies or not stated
BottleCobalt blue glass, glass dropperGlass or plastic
Why ours

3 Ways Ours Stands Apart

Era Organics Activated Methylene Blue 1%, 2 oz bottle and box

Quality you can check

Grade, testing and bottling are the parts of methylene blue you can check, so those are the parts we show you.

  1. Grade

    It starts with USP-purity methylene blue

    We buy USP-purity methylene blue from a leading lab supplier, and it comes with a certificate of analysis.

  2. Testing

    Third-party tested, reports in the open

    Purity and heavy metals (arsenic, cadmium, lead, mercury) are third-party tested. The reports for the current batch are linked in Lab results below.

  3. Made & bottled

    Made in the USA, bottled in glass

    Made in a GMP-certified facility, alcohol-free and formaldehyde-free, and filled into cobalt blue glass bottles with glass droppers.

What's inside

Four ingredients, chosen for quality

Three additions set our formula apart from plain methylene blue drops. Here's what's inside and why it's there.

  • Methylene Blue, USP Purity (99.99%)

    The heart of the formula: USP-purity, pharmaceutical grade methylene blue at 99.99% purity, from a leading lab supplier. Not the technical or lab grade most brands use.

  • Nano Gold

    Colloidal gold nanoparticles. A premium ingredient you won't find in standard methylene blue drops.

Era Organics Methylene Blue Drops
  • Fulvic Acid

    Ionic fulvic acid minerals, a naturally derived mineral complex. Together with nano gold, it is what “enhanced” on our label means.

  • Vitamin C

    Vitamin C completes the formula. With nano gold and fulvic acid, it makes ours the only 1% methylene blue formula with all three.

Full ingredient list:

Methylene Blue, USP Purity (99.99%), Colloidal Gold Nanoparticles, Ionic Fulvic Acid minerals, Vitamin C, Distilled water, *vegetable glycerine, citric acid *Organic Ingredients

Our standard

Lab results

Made with methylene blue that meets USP (United States Pharmacopeia) specifications for quality and purity.

With methylene blue, quality is the product. So we start with USP-purity methylene blue from a leading lab supplier, have our drops third-party tested for purity and heavy metals, and publish both reports for the current batch right here. Questions about a batch? Write to us.

Before you start

Getting started & tips

  • Shake well. Give the bottle a good shake before each use.
  • Measure by the drop. The glass dropper lets you count drops; each drop holds about 0.5 mg of methylene blue. For how much to use, follow the label directions.
  • Mix it with water. Add the drops to water in a glass (not plastic) and stir. It's easier to drink that way and keeps it off your teeth.
  • It stains. Methylene blue is a strong dye. It can stain skin, fabric, counters and plastic, and tint your tongue for a while. Wipe drips right away, wash your hands after, and rinse your mouth with water.
  • Taste. On its own it tastes bitter. Mixed into water or juice, the taste is much milder.
  • Storage. Close the cap tightly and keep the bottle in a cool, dark place away from sunlight, out of reach of children. Use it by the date on the bottle.

Who shouldn't use it

Talk to your doctor before using methylene blue. Don't use it if you:

  • take serotonergic medications, such as SSRIs, SNRIs or MAOIs (methylene blue can interact with them)
  • have G6PD deficiency
  • are pregnant or nursing
  • have kidney or liver disease
  • have low blood pressure
  • are allergic to methylene blue or other dyes

Keep out of reach of children. Stop using it and contact your doctor if you have a reaction. Methylene blue can turn urine blue or green.

This product is sold for research and development purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

Common questions

Everything you've asked us

Straight answers on quality, testing and handling.

How is this product classified?

This product is sold as a research compound, not a dietary supplement. It is not intended to diagnose, treat, cure, or prevent any disease.

How much should I use?

We don't give personal dosage guidance. Follow the label directions, and talk to a qualified healthcare professional before use, especially if you take any medication.

Are there any known interactions or precautions?

Methylene blue can interact with certain medications, including SSRIs, SNRIs and MAOIs, and it isn't right for everyone. See "Who shouldn't use it" above, and talk to a qualified healthcare professional before use.

Do you test your product?

Yes. It is third-party tested for purity and for heavy metals (arsenic, cadmium, lead and mercury). The reports for the current batch are in the Lab results section above.

What's in it?

USP-purity methylene blue, colloidal gold nanoparticles, ionic fulvic acid minerals, vitamin C, distilled water, organic vegetable glycerin and citric acid. No alcohol, no formaldehyde.

More about Methylene Blue Drops

Buy Activated Methylene Blue Drops 

Methylene Blue (Methylthioninium chloride) is a salt used as a dye, supplement, and medication. Methylene blue was synthesized in 1876 by Heinrich Caro.  Methylene blue was originally made as a cotton, wool, and paper dye due to its rich blue pigment. It was later discovered in the 19th century that methylene blue had medical uses.

USP Grade methylene blue drops have recently been researched for the major benefits in supporting cellular energy through improved mitochondria function, help improve brain function, promote cognition, and supporting anti-aging skin benefits according to the study in 2017 by Xiong, ZM., O’Donovan, M., Sun, L. et al. Anti-Aging Potentials of Methylene Blue for Human Skin Longevity “Oxidative stress is the major cause of skin aging that includes wrinkles, pigmentation, and weakened wound healing ability. Application of antioxidants in skin care is well accepted as an effective approach to delay the skin aging process.”

Methylene blue drops (MB) have been researched for their benefits as an oral supplement and their possibility of helping brain function, including memory and cognition, mood, cellular energy, mitochondrial function, and anti-aging properties for the skin. Aging skin is affected by oxidative stress. Oxidative stress is caused by smoking, diet, alcohol, and pollution, leading to chronic inflammation, wrinkles, sagging skin, skin sensitivity, hyperpigmentation, and signs of premature aging. Methylene blue is one of the best and least expensive potential longevity and inner beauty supplements money can buy.

Aging skin is the natural changes in the skin’s structure, function, and appearance that occur as part of the aging process. Aging skin is affected by environmental factors such as sun exposure, environmental pollution, diet and lifestyle. Visible signs of aging skin include wrinkles, sagging, dullness, dryness and age spots. As skin ages, it loses the ability to repair, heal, maintain its protective barrier and loss of firmness and elasticity due to decreased collagen, nutrients and hydration.

Activated Methylene Blue 1% is tailored to potentially support longevity, anti-aging benefits, cellular energy and brain health with key ingredients vitamin c, colloidal gold, and ionic fulvic acid to support overall wellness and healthy aging. Buy pharmaceutical grade methylene blue 1% drops for the major advantages of purity, quality, third party testing and advanced formulation for maximum absorption with no hidden alcohol, formaldehyde or chemical preservatives. Methylene blue is best used for healthy individuals to promote longevity, energy, cognitive function and healthy aging under the guidance of a healthcare provider.

Era Organics Active Methylene Blue 1% is expertly formulated with key ingredients Vitamin C, Nano Gold and Fulvic Acid for optimum bioavailability to help support cellular energy, longevity, brain health and aging skin thanks to ionic trace minerals found in fulvic acid. The main advantages of Active Methylene Blue with Nano Gold is the potential of enhanced photodynamic activity, where sunlight and red light therapy help activate MB in our cells for increased benefits. Nano Gold (colloidal gold) is a liquid suspension of gold nanoparticles used in medicine and supplements to assist in nutrient delivery. It is a powerful anti-inflammatory substance that supports healing and is a powerful antioxidant. Fulvic acid is a naturally occurring compound made from prehistoric deposits from plants breaking down- loaded with over 65 essential trace minerals and amino acids. Fulvic acid helps support gut health, nutrient absorption, mitochondria function, brain health, and cellular detoxification. Fulvic acid is a powerful inner beauty supplement that supports collagen production to boost hair, skin, and nails. Buy vitamin c, colloidal gold and fulvic acid to benefit every cell in the body and help support total health and wellness. 

Purchase Active Methylene Blue from Era Organics for quality, stability and purity- enhanced with colloidal gold and fulvic acid to potentially support more energy, less brain fog, defense against oxidative stress, healthy aging and inner beauty. Methylene Blue drops are best for men and women looking to optimize their health, brain function, wellbeing, longevity, healthy aging and clean energy under the guidance of a healthcare professional.

Why Choose Activated Methylene Blue Drops from Era Organics?

Choose Active Methylene Blue 1% Drops from Era Organics for purity, quality and unique formulation with nano gold and ancient fulvic acid for enhanced bioavailability and optimized wellness. Methylene Blue drops are researched in over 200 studies to assist in cellular energy, mental clarity, brain health, mitochondrial function, protect against damaging oxidative stress, healthy aging and inner beauty.

Oxidative stress is caused by environmental pollutants that lead to cellular damage, DNA damage, chronic disease, inflammation, cognitive function, and signs of premature aging. Oxidative stress can lead to wrinkles, hyperpigmentation, sagging skin, dark spots, and even eczema.

USP Grade Methylene Blue, Colloidal Gold, Vitamin C and Fulvic Acid may form a powerful defense to support against oxidative stress through anti-inflammatory benefits, powerful antioxidants, cellular detoxification, enhanced mitochondria function and improved gut health.

Era Organics is a family owned company with products proudly made in the USA focusing on quality and your long term health and happiness. Each product is 3rd party lab tested for quality, potency, and safety. Customer service and satisfaction are the top priorities.

What does the Methylene Blue Drops do for the Skin?

Methylene Blue 1% is researched for many potential benefits for the skin, including helping protect from oxidative stress, supporting collagen and elastin production, and stimulating cellular energy.

Methylene blue drops have powerful potential anti-aging properties for aging skin and  rejuvenation properties according to a 2017 study by Xiong, ZM., O’Donovan, M., Sun, L. et al. Anti-Aging Potentials of Methylene Blue for Human Skin Longevity found that methylene blue is a powerful anti-aging antioxidant that can help protect skin from aging by reducing damage from free radicals, assist skin cell growth, hydrate the skin, and boost skin proteins.

Premature aging is caused by damaging free radicals from pollution, UV rays, toxins and impurities. Signs of aging include fine lines, wrinkles, loss of elasticity and hyperpigmentation. which can cause cell damage. According to the study Dec 1 2021 by Huijing Xue Et al. Department of Cell Biology and Molecular Genetics, University of Maryland, methylene blue shows promising signs of boosting collagen and elastin to help keep skin firm, thicker and hydrated- even more powerful than retinol and vitamin c.

“As a potent antioxidant, MB can effectively combat ROS and prevents the accelerated aging induced by ROS.”

Era Organics Active Methylene Blue drops are made in a GMP certified facility in the USA with a unique blend of essential cofactors to maximize bioavailability and support overall wellness.

Active Methylene Blue sold by Era Organics is the only methylene blue activated with nano gold and fulvic acid to maximize the benefits for potentially supporting energy, gut, brain, longevity, aging skin and overall wellness. This unique blend of longevity supplements is stabilized in organic vegetable glycerine for stability and extended shelf life.

How does methylene blue work? Methylene blue acts as an electron carrier, boosting oxygen use in cells, reduces harmful reactive oxygen species (ROS), and supports brain health by supporting key steps in the electron transport chain. Methylene Blue helps red blood cells carry and release oxygen properly in the body, improving oxygen delivery while protecting from oxidative stress and reducing inflammation according to a study by Evangelos Bistas, June 26, 2023.

"By acting as an alternative electron acceptor/donor MB restores mitochondrial function, improves neuronal energy production and inhibits the formation of superoxide" Oct 2017 by Anzelle Delport Et al. Methylene Blue and its Analogues as Antidepressant Compounds.

Methylene blue uses include the potential for cellular energy production to battle chronic fatigue, mental clarity for those battling brain fog, cellular boost for cells, and improved cognitive function.

What Ingredients are Used for the Methylene Blue Drops?

Activated Methylene Blue is formulated with pharmaceutical grade methylene blue, colloidal gold, fulvic acid, vitamin c and organic vegetable glycerine to maximize the benefits of methylene blue drops- formaldehyde free, alcohol free and sugar free, and tested for heavy metals.

  1. USP Grade Methylene Blue: USP Grade methylene blue is a synthetic die used in medical procedures, research and is being studied for potential health benefits. Pharmaceutical grade methylene blue ensures the highest quality- tested for heavy metals and free from residual solvents, harsh preservatives or formaldehyde.
  2. Vitamin C: Fruit-sourced vitamin c, also known as ascorbic acid, is a vitamin found in fruits and vegetables. Vitamin c is a powerful antioxidant and plays a key role in regenerating other antioxidants in the body, such as methylene blue. Vitamin C may enhance methylene blue’s efficacy by increasing its bioavailability and cellular uptake. Vitamin C helps protect cells from oxidative damage, supporting the mitochondrial benefits of methylene blue and plays a key roll in immunity, collagen production- improving skin elasticity and reducing wrinkles according to a study in the Journal of Investigative Dermatology, 2017.
  3. Colloidal Gold: Colloidal Gold is sub-microscopic high purity gold particles in water. Colloidal gold, also called nano gold, is believed to enhance cognitive function, improve focus, and support nervous system health— benefits that align closely with methylene blue’s potential nootropic and neuroprotective effects. Nano gold may improve bioelectric conductivity in the body, potentially amplifying methylene blue’s mitochondrial energy support and may reduce inflammation according to the study in Nanomedicine: Nanotechnology, Biology and Medicine. 2013;9(6):882-891. DOI: 10.1016/j.nano.2013.01.004., which complements methylene blue’s potential anti-inflammatory effects in skin conditions. 
  4. Fulvic Acid Minerals: Fulvic Acid is a naturally occurring compound found in soil and decomposed plant matter that has over 70 iconic trace minerals to support overall well being. Fulvic acid aids in nutrient absorption, gut health and has chelating, antioxidant, and detoxifying properties. Fulvic acid enhances cellular nutrient absorption, potentially helping shuttle methylene blue more efficiently into mitochondria. Fulvic acid supports cellular energy production and inflammation, aligning with methylene blue’s role in reducing oxidative stress and improving mitochondrial function. Journal of Clinical Biochemistry and Nutrition, 2019. 
  5. Organic Vegetable Glycerin: Vegetable glycerin is a clear, sweet tasting liquid derived from plants. glycerin helps in digestion by drawing moisture into the gut. Glycerin provides stability, extended shelf life and better bioavailability compared to just water as a carrier for methylene blue. 
  6. Citric Acid: Citric Acid is a gentle organic acid naturally found in citrus fruits. Citric acid is used in supplements as a natural preservative or pH stabilizer. Fruit-sourced citric acid can enhance the stability and solubility. Citric acid is a compound that is a key part of the Citric Acid Cycle, also called the Krebs cycle, which is a critical process inside the mitochondria. The Krebs cycle is how your body converts food into energy (ATP) so cells can function properly and remove waste from the body. Citric acid helps support absorption and provides a slightly acidic environment to help preserve and stabilize Methylene blue.

What are the Advantages of Using Methylene Blue Drops?

The benefits of Methylene Blue are studied for potentially supporting more energy, improved cognitive function, cellular health, gut health and beauty from within according to a 2021 study by Huijing Xue in the Department of Cell Biology and Molecular Genetics, University of Maryland suggests the potential for methylene blue to boost brain energy, reduce damage from stress, improve memory, fight oxidative stress, boost skin cell growth and protect skin from sun damage. The list of methylene blue 1% drops benefits according to studies are below.

  • Supporting Cellular Energy Production: Methylene blue supports an energy boost by improving mitochondrial function through enhancing oxygen use and reducing oxidative stress, allowing your cells to produce energy more efficiently. 
  • Supporting Brain Health: Methylene Blue helps improve cognitive clarity to combat brain fog and chronic fatigue by increasing the efficiency of brain cell activity through increased oxygen use in the brain and reducing oxidative damage that can impair cognitive performance. Methylene blue may help sharper focus, better memory and improved mental clarity. 
  • Enhances Mood: Methylene blue may aid in mood by helping reduce excess Reactive Oxygen Species (ROS) that can harm brain cells. Reducing ROS helps protect neurons (brain cells) from damage. 
  • Amplifies Memory: Methylene blue may assist memory by increasing energy and oxygen use in the brain. Memory can weaken as the body ages due to weakening mitochondria. Animal tests show it makes them better at remembering things and human brain scans suggest methylene blue assists the brain networks to stay sharp. Methylene blue’s antioxidant activity is being researched to see if it can help slow damage to the skin or improve age-related memory 
  • Reduce Oxidative Stress: Methylene blue and nano gold act as a powerful antioxidant to reduce oxidative stress to help protect cells from damage. Oxidative stress occurs when the body produces more free radicals than it can neutralize, which can cause cellular damage. Oxidative stress can contribute to premature aging, chronic disease, inflammation and cognitive decline.

Methylene Blue Supplement Use

Methylene blue is not approved as a dietary supplement. Methylene blue supplement use is considered off label, used for research and experimented with by neurohackers and alternative medicine. Methylene blue is currently sold for research and development purposes only.

Important: Use under the guidance of a healthcare provider. Do not mix with serotonergic drugs (SSRIs, SNRIs and MAOIs) or use while pregnant or nursing. 

Warning: If you have a medical condition or are taking medication, contact a physician before taking this supplement. Keep out of reach of children. See FAQ for more details.

Does Methylene Blue Drops Have Side Effects? 

Yes, methylene blue can have side effects, particularly in high doses when used intravenously including allergies, blue urine, leg pain, changes in skin color, increased sweating, muscle or joint pain. Methylene blue should not be used with selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors as it may cause serious or fatal serotonergic syndrome. Avoid using it in patients with severe kidney impairment. Methylene blue ingested has not been fully studied for side effects. Methylene blue IV treatment is Generally Recognized As Safe at the dosage of 2mg/kg. Methylene blue supplement dosage is suggested at just 10mg a day.

How does methylene blue drops work? 

Methylene blue works by giving electrons to hemoglobin (the part of the blood that carries oxygen)  so it can function properly and deliver oxygen to the cells. Inside the mitochondria (the cells’ power plants) methylene blue improves energy production by helping them utilize oxygen more efficiently. Methylene blue also helps cut down on ROS (Reactive Oxygen Species), which are molecules that are highly reactive due to unpair electrons, produced as a byproduct of normal cellular metabolism. Some levels of ROS are necessary, however an excess can damage cellular components like DNA, proteins and lipids- leading to oxidative stress. Methylene blue helps cut down harmful ROS by rerouting electrons away from trouble spots, breaking the cycle of stress and helping maintain cellular health.

How is the Shipment Process for Era Organics for Methylene Blue Drops?

The shipment process for Era Organics Methylene Blue 1% Drops include packaging with in 1 business day. Shipping time will be 3-5 business days after shipment.

What is the Refund Policy for Era Organics for Methylene Blue Drops?

The refund policy for Era Organics Methylene Blue 1% Drops is a fully 60 day “love it or your money back” guarantee. Buy Activated Methylene Blue and try for a full two months and if you don’t love it, simply return it for a full refund, even if you used up the whole bottle.

Methylene Blue Drops Cautions and Warnings

Methylene blue is still being studied for its uses, benefits, and side effects. People with certain conditions must  avoid use based on studies regarding methylene blue medical treatments. Use Methylene blue  under the advice of a healthcare professional. Discontinue use and consult your physician immediately if adverse reactions occur.

Methylene Blue is currently sold for research and development purposes only.

Medications: Methylene blue should not be used in combination with selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs). Methylene blue may cause serotonergic syndrome when used in combination with serotonergic drugs. 

Nursing and Pregnancy: Methylene blue use during pregnancy and nursing is not well established and must be avoided. Nursing moms must avoid it because it tends to transfer into the breastmilk.  

Kidney Disease: Patients with severe kidney impairment must avoid methylene blue. Patients with kidney disease or impaired renal function must avoid or be monitored by a healthcare professional. 

Liver Disease: Patients with liver disease or impaired liver function must be monitored closely by a healthcare professional or avoid use of methylene blue since the liver metabolizes methylene blue. 

Hypotension: Methylene blue can lower blood pressure, so people with hypotension (low blood pressure) must be monitored closely by a healthcare professional or avoid use. 

Allergies: Individuals with known allergies to methylene blue or other dyes should avoid use.

G6PD: Individuals with G6PD Deficiency (glucose-6-phosphate dehydrogenase), a genetic enzyme disorder, should avoid use of methylene blue. 

Children: Methylene blue is generally considered safe when used as a dye for diagnostic purposes, but it must be carefully considered as a medication in pediatric patients.

 

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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